What is it about?
Giant Axonal Neuropathy (GAN) is a rare disease that leads to low levels of gigaxonin, leading to aggregates of intermediate filaments. This study describes a proteomic approach to understand what Gigaxonin binds to. The kelch domian was found to be important along with HSP90 and Myc binding to the BTB domian.
Why is it important?
This work could lead to targets for drug discovery to treat this rare disease - by clearing the accumulated intermediate filaments that are present in GAN patients.
The following have contributed to this page: Dr Sean Ekins