What is it about?
We report that inflammation induced by peritoneal injection of heat-killed bacteria in asymptomatic frogs one month after infection with FV3 resulted in viral reactivation including detectable viral DNA and viral gene expression in otherwise asymptomatic frogs. FV3 reactivation was most prominently detected in kidneys and in peritoneal mononuclear phagocytes. Notably, unlike adult frogs that typically clear primary FV3 infections, a proportion of the animals succumbed to the reactivated FV3 infection, indicating that previous exposure does not provide protection against subsequent reactivation in these animals.
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Perspectives
This is first study providing concrete evidence of the roles of macrophage-lineage cells in the persistence of ranavirus infections in otherwise resistant and asymptomatic hosts. Furthermore, our findings that inflammatory stimuli such as bacterial challenge can reactivate and reestablish previously dormant ranavirus infections to the detriment of the amphibian hosts, reflect a previously unappreciated mechanism of RV dissemination. This remarkable persistence capacity of ranavirus in host serving as reservoir is likely contributing to the rapid expansion of these pathogens and the amphibian decline.
Dr Jacques Robert
Jacques Robert
Read the Original
This page is a summary of: Inflammation-Induced Reactivation of the Ranavirus Frog Virus 3 in Asymptomatic Xenopus laevis, PLoS ONE, November 2014, PLOS,
DOI: 10.1371/journal.pone.0112904.
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