What is it about?
We analyzed hepatitis C (HCV) subtypes and the existence of variants resistant to protease inhibitors, drugs used for HCV treatment, and their association with demographic and potential risk factors involved in the spread of HCV in a group of Brazilian blood donors.
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Why is it important?
HCV has a high genetic variability and is classified into seven major genotypes and over 100 subtypes that vary with regard to their geographic distribution, risk factors associated with infection, and response to treatment.
Perspectives
Mutations conferring resistance to NS3 inhibitors were frequent in treatment-naïve blood donors but could not be associated with any risk factor. The presence of these mutations that have replicative capacities comparable to nonresistant strains could be important for predicting response to antiviral triple therapy.
Dr Cesar de Almeida-Neto
Faculty of Medicine, University of São Paulo
Read the Original
This page is a summary of: HCV Genotypes, Characterization of Mutations Conferring Drug Resistance to Protease Inhibitors, and Risk Factors among Blood Donors in São Paulo, Brazil, PLoS ONE, January 2014, PLOS,
DOI: 10.1371/journal.pone.0086413.
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