Deriving neural crest derivatives from various sources

What is it about?

Sympathoadrenergic progenitors are the putative cells of origin of Neuroblastoma, however, it remains difficult to isolate sufficient numbers of these cells for investigations. We set out to improve generation of SAPs by using two complementary approaches, differentiation from murine embryonic stem cells (ESCs) and isolation from postnatal murine adrenal glands.

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Why is it important?

These advances in deriving sympathoadrenergic cells from various sources, facilitate investigations about the development and malignant transformation of the sympathetic PNS.