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This protein has two SUMO-like domains and interacts with the Smc5/6 complex. It is required or theDNA damage response. This paper describes a characterisation of the SUMO-like domains and the effect of various mutations of protein function.
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This page is a summary of: Characterisation of the SUMO-Like Domains of Schizosaccharomyces pombe Rad60, PLoS ONE, September 2010, PLOS,
DOI: 10.1371/journal.pone.0013009.
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Resources
The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair
Initial cloning of the rad18 gene
Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage
Important paper on the description of a novel SUMO E3 ligase associated with the Smc5/6 complex.
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