What is it about?
T-cells play a key role in protective and pathogenic responses in Chagas disease. Here we explore the role of T-cell subpopulations with specific T-cell receptors in the establishment of these responses, especially with the development of the severe cardiac form of the disease.
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Why is it important?
Identifying these cells and their functional characteristics can uncover potential targets for vaccine candidates when they are related to protective responses, or as targets for immunotherapy if they are involved with disease progression and severity.
Perspectives
This review brings together the main findings regarding T-cell repertoire in experimental and human T. cruzi infection. While there are few studies in the area, the findings are enlightening and interesting when put together. I hope this can aid in new antigen discovery for vaccines, and in designing new strategies for control of disease pathology.
Walderez Dutra
Universidade Federal de Minas Gerais
Read the Original
This page is a summary of: T-cell receptor variable region usage in Chagas disease: A systematic review of experimental and human studies, PLoS Neglected Tropical Diseases, September 2022, PLOS,
DOI: 10.1371/journal.pntd.0010546.
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