The Diagnostic Sensitivity of Dengue Rapid Test Assays Is Significantly Enhanced by Using a Combined Antigen and Antibody Testing Approach

  • Chang-Yi Huang, Andrea Valks, Paul R. Young, Matthew A. Cooper, Scott R. Fry, Michelle Meyer, Matthew G. Semple, Cameron P. Simmons, Shamala Devi Sekaran, Johnny X. Huang, Catriona McElnea
  • PLoS Neglected Tropical Diseases, June 2011, Public Library of Science (PLoS)
  • DOI: 10.1371/journal.pntd.0001199

How to make the most sensitive test for Dengue Fever

What is it about?

The effect of combining direct, best in class, reagents for detecting dengue virus antigen (NS1), and the immunological response from the patient to infection, is tested using samples from Vietnam, Thailand and Malaysia

Why is it important?

Current tests on the market only look at one maker of dengue infection. We show that combining immunoassay (viral antigen) and serological (patient antibody) tests together increases diagnostic sensitivity to 90%

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The following have contributed to this page: Matthew Cooper