What is it about?
The body is made up of individual cells that are frequently exposed to mechanical and/or chemical stressors that can compromise the integrity of its cortex (plasma membrane and underlying cytoskeleton). It is essential for cells to have robust repair mechanisms that can be rapidly deployed to avoid further damage, prevent infection/death, and restore normal function. This study investigates the molecular mechanisms governing the cell wound repair process.
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Why is it important?
Despite its importance, the molecules, machineries, signals, and pathways that initiate the immediate cell wound repair response are largely unknown. This study used a genetic approach to identify 253 genes required for the repair process. Intriguingly, a subset of these genes are involved in insulin signaling that is needed to control actin cytoskeleton dynamics during the repair process. Thus, this study is providing a unique entry point to examine the cellular machineries required for re-sealing the membrane, as well as to help build a much-needed framework for understanding the molecular pathways controlling these processes.
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This page is a summary of: Autocrine insulin pathway signaling regulates actin dynamics in cell wound repair, PLoS Genetics, December 2020, PLOS, DOI: 10.1371/journal.pgen.1009186.
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