What is it about?

Glucose is a critical nutrient for macrophages, and they use it as an energy source to carry out their functions. When macrophages encounter Salmonella, the bacteria trigger a series of changes in the macrophages' metabolism that result in a reduction in glucose uptake and utilization. This reduction in glucose metabolism leads to a decrease in the macrophages' ability to engulf and destroy the bacteria.

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Why is it important?

Understanding how Salmonella evades the immune response by manipulating macrophage glucose metabolism is important because it can help identify new targets for developing treatments to combat infectious diseases caused by microbes such as Salmonella. Additionally, this research can also contribute to a better understanding of the molecular mechanisms behind bacterial evasion of the immune system, which may have implications for the development of treatments for other bacterial infections as well.


From a scientific perspective, this research has provided important insights into the molecular mechanisms behind bacterial evasion of the immune system. It has highlighted the critical role of host cell metabolism in the immune response and has identified new targets for developing treatments to combat Salmonella infections. Ongoing research in this area will likely continue to uncover new insights into the complex interactions between host cells and pathogens. From a public health perspective, understanding how Salmonella evades the immune response is critical for developing effective treatments for Salmonella infections. Salmonella is a significant cause of foodborne illness worldwide, and infections can range from mild gastroenteritis to life-threatening typhoid fever. The development of new treatments for Salmonella infections could improve the outcome for patients and reduce the burden of this disease on public health systems.

Nirmal Robinson
University of South Australia

Read the Original

This page is a summary of: Salmonella Typhimurium impairs glycolysis-mediated acidification of phagosomes to evade macrophage defense, PLoS Pathogens, September 2021, PLOS,
DOI: 10.1371/journal.ppat.1009943.
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