What is it about?

For functional communication, the cells of immune system must establish direct contact between each other. Some bacterial pathogens evolved tools allowing them to block direct contact between an infected cells and their counterpart. One such pathogen is Salmonella that targets CD97, a protein stabilizing the contact between two communicating cells.

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Why is it important?

Understanding how our cells communicate and how this is exploited by bacterial pathogens could help us to design new therapeutic strategies.

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This page is a summary of: CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD, PLoS Pathogens, July 2021, PLOS,
DOI: 10.1371/journal.ppat.1009771.
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