What is it about?

The study tackles the problem of slow, often unreliable urine-culture testing for urinary tract infections (UTIs). By analyzing routine urinalysis and flow-cytometry data from more than 2,600 adults, the authors created a rapid “UTIRisk” score that predicts whether a patient truly has a UTI within minutes. In both the main and validation groups the score showed good accuracy—especially high specificity—suggesting it could cut unnecessary cultures and curb empirical antibiotic use, which is critical for managing resistance in low- and middle-income settings.

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Why is it important?

Rapid, reliable UTI diagnosis matters because the current “gold-standard” culture takes 24–72 hours and often misses infections, forcing clinicians to guess and prescribe broad-spectrum antibiotics “just in case.” That guesswork fuels antibiotic resistance, drives up costs, and delays proper treatment—problems that hit low- and middle-income countries hardest. A point-of-care score like UTIRisk, built from tests every clinic already runs, lets doctors rule in or out a true infection within minutes. This means fewer unnecessary cultures, more targeted antibiotic use, quicker relief for patients, and a practical tool for slowing the global rise of drug-resistant bacteria.

Perspectives

We demonstrate that routine urinalysis and flow-cytometry data can be distilled into a real-time UTIRisk score that swiftly flags true UTIs. Deployed within lab systems, it would let us reserve cultures and antibiotics for high-risk patients, trimming costs and curbing resistance—especially in resource-limited settings. This novel algorithmic upgrade could be replicated for other common infections.

Thien Tan Tri Tai Truyen
Tan Tao University

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This page is a summary of: Development of a novel risk score for diagnosing urinary tract infections: Integrating Sysmex UF-5000i urine fluorescence flow cytometry with urinalysis, PLOS One, May 2025, PLOS,
DOI: 10.1371/journal.pone.0323664.
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