What is it about?

We have 2 different physical activity programs (a basic physical training (BPT) emphasizing strength and resistance and a BPT combined with functional exercises targeting the sensorimotor pathways that are most affected in Parkinson Disease (proprioception-balance-coordination) together with cognitive and motor training (Dual task training). Skin fibroblasts are biopsed before and after intervention and mitochondrial function is analyzed

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Why is it important?

Understanding the regulation of the mitochondrial function by physical activity in Parkinson Disease holds significant promise in defining interventions to delay disease onset and developing new therapeutic approaches


By investigating the beneficial mechanisms associated with physical activity and studying the pathophysiological alterations within fibroblasts, this research holds the potential to deepen our understanding of Parkinson disease and facilitate the development of novel diagnostic tools, and revolutionary therapeutic interventions applicable to clinical practice.

Joel Montane
Fundacio Blanquerna Universitat Ramon Llull

Read the Original

This page is a summary of: Investigating the impact of physical activity on mitochondrial function in Parkinson’s disease (PARKEX): Study protocol for A randomized controlled clinical trial, PLoS ONE, November 2023, PLOS,
DOI: 10.1371/journal.pone.0293774.
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