Factors Affecting HIV-Free Survival in Infants in Nairobi County

What is it about?

This study aimed to determine the prognostic factors influencing HIV-free survival among infants enrolled for HIV early infant diagnosis (EID) services in selected hospitals in Nairobi County, Kenya. A prospective cohort study design was adopted, recruiting 166 HIV-exposed infants. The 12-month follow-up period revealed an incidence rate of 9 cases per 100 person-years, with 13 infants testing positive for HIV. Key factors influencing infant HIV-free survival included maternal ART regimen, number of PMTCT visits, and knowledge of partner's HIV status. The study found a lower HIV-free survival rate compared to other African countries, but higher than some countries like South Africa. Maternal age, unemployment, and low household income were associated with poor infant HIV-free survival. The study suggests creating a special care package for younger mothers and those recently diagnosed with HIV.

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Why is it important?

This study is important because it focuses on pediatric HIV infection, a preventable disease that still poses a significant public health concern due to morbidity and mortality associated with the disease. The research investigates the factors affecting HIV-free survival among infants enrolled in HIV early infant diagnosis (EID) services in Nairobi County, Kenya. This information is crucial for understanding the challenges faced in preventing vertical transmission of HIV and can help tailor intervention strategies to improve infant outcomes. Key Takeaways: 1. The vertical transmission rate of HIV in sub-Saharan Africa, particularly in Kenya, remains high, with room for improvement in reducing transmission rates. 2. Factors influencing HIV-free survival among infants include maternal ART regimen, number of PMTCT visits, and knowledge of partner's HIV status. 3. Maternal age, unemployment, and low household incomes were found to negatively impact infant HIV-free survival. 4. Early diagnosis and treatment for mothers can significantly improve infant HIV-free survival and reduce the chances of transmission.