What is it about?

We discovered that Bruton's tyrosine kinase (BTK), the key molecule of B-cell antigen receptor signaling pathway is over expressed in orbital fibroblasts from GO, and BTK suppression by ibrutinib treatment suppressed of inflammatory cytokine production.

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Why is it important?

Ibrutinib is an orally bioavailable medication for B-cell malignancies and chronic graft-versus-host disease, and our result suggests possibility of ibrutinib as a potential treatment for GO.


Further studies are needed to evaluate the role of BTK and its inhibitors in inflammatory response in GO in clinical settings.

Hyun Young Park
Yonsei University

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This page is a summary of: Therapeutic effect of ibrutinib, a selective Bruton’s tyrosine kinase inhibitor, in orbital fibroblasts from patients with Graves’ orbitopathy, PLoS ONE, December 2022, PLOS,
DOI: 10.1371/journal.pone.0279060.
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