What is it about?

Lactic acid bacteria (LAB) are now receiving increasing attention as food additives. A novel LAB named D279 (Latilactobacillus sakei) was identified from pickles. In the murine influenza model, the group administered with D279 showed no mortality after virus infection, suggesting that D279 has a potent effect on immunity. We investigated and discussed how D279 helped alleviate flu symptoms.

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Why is it important?

Probiotic bacteria are crucial for maintaining the quality of life in a stressed society. Thus, the demand for functional LAB is increasing rapidly. Our findings indicate that D279 is a promising strain for future food materials.


Mice treated with D279 demonstrated a significant improvement in survival rates after viral infection. As far as I know, a survival rate of 100% for the D279-treated group in the influenza infection test is uncommon. I believe that D279 is a practical and functional LAB that can be utilized in food materials. The intriguing aspect is that D279 does not induce type I IFN significantly, yet it shows a favorable effect against the virus. This suggests that D279 promotes a strong balance in innate immunity. I think that our article may be useful to researchers studying probiotics or food.

Yuto Takenaka
Mitsubishi Gasu Kagaku Kabushiki Kaisha

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This page is a summary of: Identification of novel lactic acid bacteria with enhanced protective effects against influenza virus, PLoS ONE, August 2023, PLOS,
DOI: 10.1371/journal.pone.0273604.
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