What is it about?

Knee osteoarthritis (OA) is a common cause of pain and disability, but every person's knee OA is different. There are various risk factors, causes, and outcomes from this condition, but how to best define these subgroups is unknown. This paper uses a method developed for gene expression data to cluster knees by baseline clinical features in order to better define these subgroups.

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Why is it important?

Identifying subgroups of people at high risk for worse outcomes could allow for more aggressive management in these groups, or highlight groups who would potentially benefit from targeted interventions in a clinical trial setting.

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This page is a summary of: Biclustering reveals potential knee OA phenotypes in exploratory analyses: Data from the Osteoarthritis Initiative, PLoS ONE, May 2022, PLOS, DOI: 10.1371/journal.pone.0266964.
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