Metal nanoparticles assisted revival of Streptomycin against MDRS Staphylococcus aureus

What is it about?

The article "Metal nanoparticles assisted revival of Streptomycin against MDRS Staphylococcus aureus" explores a novel approach to combat antibiotic-resistant bacterial strains, specifically multidrug-resistant Staphylococcus aureus (MDRS). The authors propose the use of metal and metal oxide nanoparticles to assist the antibiotic streptomycin in its activity against the MDRS strain. The study involved the green synthesis of NPs of various metals, including silver, zinc, copper, and, iron by using leaf extract of Ricinus communis and testing their effectiveness in combination with streptomycin against MDRS strains of Staphylococcus aureus. The results indicated that all the prepared NPs significantly enhanced the antibacterial activity of streptomycin against the MDRS strain of S. aureus. The highest enhanced antibacterial potential of Streptomycin was observed in conjugation with ZnO NPs (11 ± 0.5 mm) against S. aureus. The considerable point of the present investigation is that S. aureus, which was resistant to streptomycin becomes highly susceptible to the same antibiotic when combined with nanoparticles. The authors suggest that the mechanism of action involves the NPs disrupting the bacterial cell membrane, thereby facilitating the entry of streptomycin into the bacterial cell and enhancing its activity. The study highlights the potential of NPs as an adjuvant therapy to combat antibiotic resistance and the need for further research in this area. Overall, the article presents an innovative approach to addressing the challenge of antibiotic resistance and demonstrates the potential of green synthesized nanoparticles in enhancing the effectiveness of existing antibiotics against multidrug-resistant bacterial strains. This study has important implications for the development of new strategies to combat antibiotic resistance.

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Photo by CDC on Unsplash

Photo by CDC on Unsplash

Why is it important?

Our findings show an alternative to discovering new antibiotics for multi drug resistant microbes. Instead we can activate existing antibiotics against resistant microbes.