What is it about?
This paper compares brain structure in newborns with two common conditions with risk of altered brain development or early brain injury. The paper finds that each condition affects the brain differently. Differences in global brain network structure are identified and associated with specific functional outcomes.
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Why is it important?
Brain imaging can illuminate structural network differences and predict function. The results may prove useful for developing early predictive models and targeted interventions in newborns.
Perspectives
This project was possible because of the generosity and courage of families who agreed to participate in research during an unknowably stressful time after birth of their critically ill newborn. The work also required the expertise of vast team of experts including surgeons, radiologists, biomedical imagers, critical care physicians and nurses, neuropsychologists and coordinators. The ultimate goal for both families and research team is to help newborns who were sick at birth, survive, grow and thrive.
Patrick McQuillen
University of California, San Francisco
Read the Original
This page is a summary of: Neonatal brain injury influences structural connectivity and childhood functional outcomes, PLoS ONE, January 2022, PLOS,
DOI: 10.1371/journal.pone.0262310.
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