What is it about?
Trabecular meshwork constitutes the conventional outflow pathway and controls intraocular pressure by regulating aqueous outflow. We have investigated that how transient receptor potential cation channel subfamily V member 4 functions in trabecular meshwork and affects intraocular pressure.
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Why is it important?
Our findings suggest that TRPV4 mediates the cellular response induced by trabecular meshwork stretch, leading to IOP reduction through the production of prostaglandins and inhibition of cell contraction.
Perspectives
I have grown as a researcher through this study. I hope that this article will help glaucoma patients, directly or indirectly.
Takatoshi Uchida
Read the Original
This page is a summary of: TRPV4 is activated by mechanical stimulation to induce prostaglandins release in trabecular meshwork, lowering intraocular pressure, PLoS ONE, October 2021, PLOS,
DOI: 10.1371/journal.pone.0258911.
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