What is it about?
GDNF potential is promising for translation to treat diseases associated with neuronal death: neurodegenerative disorders, ischemic stroke, and cerebral or spinal cord damages. In this work , different forms of GDNF synthesized from sources such as E.coli and HEK293 were obtained . For the first time, it was shown that the neuroinductive properties of GDNF directly depend on the source of synthesis, so the neuroinductive activity is higher when using mammalian cells as GDNF producers.
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Why is it important?
Neurodegenerative diseases, such as Alzheimer's disease (30% of the population over 85 years old) and Parkinson's disease (2% of the population over 65 years old), are among the most socially significant diseases caused by impaired functions of nerve cells and their death. At the moment, the options are the relieving of the symptoms and decreasing the disease progression, and no cures exist. The search for a therapeutic agent and methods of its application is still being intensively conducted. Further modifications of the methods and doses of factor administration may lead to more stable positive clinical trials. Other approaches to efficient GDNF application may include molecular modifications of the recombinant factor and generation of transgenic producer cultures.
Perspectives
Further researches focused on the production of modified GDNF isoforms from mammalian cells and investigation their secretion pathways, as well as their interaction with cell receptors are required. The search for small molecules based on GDNF and able pass the blood-brain barrier and analysis of their neurotrophic potential for clinical use in neurodegenerative diseases are to be continued.
Dzhirgala Shamadykova
Institute of Higher Nervous Activity and Neurophysiology of RAS
Read the Original
This page is a summary of: Neuroinductive properties of mGDNF depend on the producer, E. Coli or human cells, PLoS ONE, October 2021, PLOS,
DOI: 10.1371/journal.pone.0258289.
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