What is it about?

Candida is an opportunistic pathogen and one of the most common cause of fungal infections worldwide. Even though some commercially available anti-fungal agents are used to treat the candida infection, resistant Candida is a main problem. One of the reasons is biofilm. The anti-biofilm activity of Hedera rhombea extract showed dose dependent reduction of the biofilm formation of Candida. H. rhombea extract also increased the antifungal susceptibility of miconazole, blocked the dimorphic transition from yeast to hyphae form, and reduced the adherence of candida to the host cells Because of its anti-Candida biofilm formation effect with increased antifungal susceptibility and reduced virulence, Hedera rhombea extract may serve as antifungal adjuvant to develop a new antifungal agent.

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Why is it important?

Biofilm is one of the main problems for microbial infection and thereby lots of researchers have been trying to find the solution for that. Hedera rhombea extract can be a one of candidates to control that.


This paper showed how to manage the candida infection in the future including regulation of virulence factors.

Ki-Young Kim
Kyung Hee University

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This page is a summary of: Hedera rhombea inhibits the biofilm formation of Candida, thereby increases the susceptibility to antifungal agent, and reduces infection, PLoS ONE, October 2021, PLOS,
DOI: 10.1371/journal.pone.0258108.
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