What is it about?
As we know that collagen is naturally lost according to aging, not only that, it also decreases in several types of cancer including breast. Our research found that one type of collagen, called collagen XVII, played important role in controlling breast cancer cell growth and proliferation. Collagen XVII deactivated the AKT/mTOR signaling pathway by inhibiting the phosphorylation of molecules responsible for cell growth and proliferation. Breast cancer cells that were genetically engineered to express high collagen XVII levels exhibit an anti-proliferative effect, delayed tumor progression, and prolonged survival time.
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Why is it important?
It is of interest that the tumor microenvironment, such as collagen protein, is involved in tumor progression and invasiveness. Our study suggests the potential role of collagen XVII as a novel target for breast cancer treatment.
Perspectives
Collagen XVII is an interesting molecule to be targeted in breast cancer treatment.
Varalee Yodsurang
Chulalongkorn University
Read the Original
This page is a summary of: Collagen XVII inhibits breast cancer cell proliferation and growth through deactivation of the AKT/mTOR signaling pathway, PLoS ONE, July 2021, PLOS,
DOI: 10.1371/journal.pone.0255179.
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