What is it about?
Both inflammation and oxidative stress may be involved in the pathophysiology of postoperative delirium. The neutrophil-lymphocyte ratio, derived directly from the differential white blood cell count, is an easily applicable marker of inflammation and oxidative stress. This study showed the preoperative neutrophil-lymphocyte ratio may be a good predictor of postoperative delirium in patients undergoing head and neck free-flap reconstruction.
Featured Image
Photo by Alexander Grey on Unsplash
Why is it important?
Postoperative delirium is one of the most common postoperative complications. Postoperative delirium is associated with a decreased quality of life, prolonged hospital length of stay, and increased morbidity and mortality after major surgery. Preventing postoperative delirium in patients undergoing head and neck reconstruction surgery is important because postoperative delirium can affect the flap blood flow and contribute to the development of postoperative cognitive dysfunction. More highly sensitive predictive models for postoperative delirium are urgently required to improve patients’ outcomes. Therefore, we conducted the present study to determine whether the preoperative neutrophil-lymphocyte ratio can serve as an effective predictor of postoperative delirium after head and neck free-flap reconstruction.
Perspectives
The neutrophil-lymphocyte ratio is an easily applied marker of inflammation and oxidative stress. Although the neutrophil-lymphocyte ratio may suggest a neuroinflammatory condition, the detailed pathogenesis and underlying mechanisms require further study.
Hirotaka Kinoshita
Hirosaki Daigaku
Read the Original
This page is a summary of: Availability of preoperative neutrophil-lymphocyte ratio to predict postoperative delirium after head and neck free-flap reconstruction: A retrospective study, PLoS ONE, July 2021, PLOS,
DOI: 10.1371/journal.pone.0254654.
You can read the full text:
Contributors
The following have contributed to this page
