What is it about?
Mouse models that develop hypertension are widely used to study the cause of high blood pressure in people. Blood pressure high (BPH) mice have a genetic predisposition for developing hypertension but the primary genes involved were previously unknown.
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Why is it important?
Humans have high blood pressure for many different reasons. Multiple genes are often involved and therefore the cause is polygenic. A mouse that also has a polygenic predisposition for hypertension is therefore a useful model for studying the cause of high blood pressure in people.
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This page is a summary of: Genotypic analysis of the female BPH/5 mouse, a model of superimposed preeclampsia, PLoS ONE, July 2021, PLOS,
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