What is it about?

Mouse models that develop hypertension are widely used to study the cause of high blood pressure in people. Blood pressure high (BPH) mice have a genetic predisposition for developing hypertension but the primary genes involved were previously unknown.

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Why is it important?

Humans have high blood pressure for many different reasons. Multiple genes are often involved and therefore the cause is polygenic. A mouse that also has a polygenic predisposition for hypertension is therefore a useful model for studying the cause of high blood pressure in people.


One-third of adults in the United States have high blood pressure. Blood pressure high (BPH) mice can be used to study the pathogenesis of high blood pressure across the lifespan. They can also be used to develop preventative strategies, diagnostics, and therapeutics that may improve the health of people predisposed to developing hypertension.

Jenny Sones
Colorado State University

Read the Original

This page is a summary of: Genotypic analysis of the female BPH/5 mouse, a model of superimposed preeclampsia, PLoS ONE, July 2021, PLOS,
DOI: 10.1371/journal.pone.0253453.
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