What is it about?

Resistance for HIV therapeutic drugs challenges the treatment of children living with HIV. There is a critical lack of data concerning the performance (clinical success) of HIV treatment in Ethiopian children, especially second-line treatment drugs (the ones you give when the most often or first-line drugs do not work any more). Our study describes the outcomes of children and adolescents receiving second line HIV treatment in two referral hospitals, Yekatit 12 and Zewditu Memorial Hospitals, in Addis Ababa, Ethiopia.

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Why is it important?

Little is known about the success of second line HIV therapy among children in Ethiopia. Our study provides critical insight among large groups of children under follow-up at two referral hospitals in Ethiopia.


The performance of second line antiretroviral treatments for children and adolescents under care at pediatric HIV clinics in two referral hospitals in Addis Ababa, Ethiopia is described in this research. This study Improves the depth of knowledge of health workers and encourages frequent monitoring of treatment performance and early initiation of treatment, improving laboratories’ capacity including their ability to conduct pre-treatment anti-retroviral drug resistance testing and adherence counseling in children and adolescents living with HIV.

Tinsae Alemayehu
St. Paul's Hospital Millennium Medical College

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This page is a summary of: Clinical, immunologic and virologic outcomes of children and adolescents receiving second line anti-retroviral therapy in two referral hospitals in Addis Ababa, Ethiopia, PLoS ONE, March 2021, PLOS,
DOI: 10.1371/journal.pone.0249085.
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