What is it about?
We identified the gene, BRD2, as a cause of a specific form of human epilepsy. A standard way of proving one has identified the correct gene locus is to create a mouse model by changing the gene in mice and determining if the disease is reproduced in the mice. We successfully produced a seizure-susceptible mouse but we also noticed that those mice with the genetic change that produced the seizure-susceptibility also not only lived significantly longer than littermates without the change but also had fewer pathologies typically seen in older mice, pathologies such as cancer and kidney disease, and increased healthy behavior such as fertility and grooming.
Photo by Nick Fewings on Unsplash
Why is it important?
This serendipitous observation suggests that an emphasis on metabolism-related genes in longevity, which is prominent in the literature, may be missing much of the background for increasing life- and health-span.
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This page is a summary of: Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice, PLoS ONE, June 2020, PLOS,
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