What is it about?
The protein DNA Methyltransferase 1 (DNMT1) is important for cancer initiation and progression, making it a potential cancer drug target. Using a variety of biochemical assays, we identified two new inhibitors of DNMT1 that share structural features with a known DNMT1 inhibitor. The newly discovered inhibitors have a simpler structure, making them easier to make than the known inhibitor.
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Why is it important?
DNA Methyltransferase 1 (DNMT1) is an interesting cancer drug target, but current therapeutics lack specificity and cause negative side effects in humans. New inhibitors with increased specificity are needed. We identified new inhibitors of DNMT1 that are easier to make than other known inhibitors. These newly discovered compounds could be further developed into new cancer drugs.
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This page is a summary of: Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors, PLoS ONE, July 2019, PLOS,
DOI: 10.1371/journal.pone.0219830.
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