What is it about?

The purpose of the current study was to evaluate the effect of 12/15- lipoxygenase (12/15-LOX) metabolites on retinal endothelial cell (REC) barrier function

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Why is it important?

12/15-LOX contributes to vascular hyperpermeability during DR via NADPH oxidase dependent mechanism which involves suppression of protein tyrosine phosphatase and activation of VEGF-R2 signal pathway.


The current study proposes 12/15-LOX pathway as a potential therapeutic target to prevent the development and progression of DR. suprresion of this pathway could ameliorate DR.

Dr Nasser M Rizk
Mansoura University

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This page is a summary of: 12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase, PLoS ONE, February 2013, PLOS,
DOI: 10.1371/journal.pone.0057254.
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