What is it about?
Fetal male germ cells require the protein DND1 to their ultimate development into sperm in adults. Developmental processes regulated by DND1 in male germ cells shortly before birth establish male fertility. We identified DND1 regulatory targets involved in protecting fertility, and defined how changes in DND1 dosage impact some of these regulatory events.
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Why is it important?
The transition of fetal male germ cells to spermatogonial stem cells is a critical transition around birth that establishes lifelong male fertility.
Perspectives
From a methods standpoint, we used an integrated analysis approach on a super-series of sequencing data. For anyone wishing to apply our method their own system the complete script is available as part of the published data. To be more visually inclusive most of the figures use the Ito-Okabe Color Universal Design palette and we hope these figures serve as a model for how to equitably visualize sequencing data.
Victor Ruthig
Weill Cornell Medicine
Read the Original
This page is a summary of: The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation, PLoS Genetics, March 2023, PLOS,
DOI: 10.1371/journal.pgen.1010656.
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