What is it about?

In this work, we use experimental and modeling approaches to estimate the surface density of the glial glutamate transporters GLAST and GLT-1 in mouse hippocampal astrocytes. The results show that the surface density of glutamate transporters in hippocampal astrocytes is similar in 7–8 week old mice and rats. In mice, GLAST and GLT-1 reach their peak expression at*6 months of age. Their expression, however, varies widely across different sub-cellular compartments. These findings indicate that the identity of the sub-cellular compartment of an astrocyte in contact with a glutamatergic synapses, in addition to the extent of its synaptic coverage, is a main factor to limit glutamate spillover and receptor activation at a distance from the release site.

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Why is it important?

This work provide important information for understanding the role of astrocytes in extracellular glutamate uptake.

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This page is a summary of: Estimating the glutamate transporter surface density in distinct sub-cellular compartments of mouse hippocampal astrocytes, PLoS Computational Biology, February 2022, PLOS,
DOI: 10.1371/journal.pcbi.1009845.
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