What is it about?
We analyze all known genomes that have been properly annotated to look for syntenic sequences and check if their evolution on gene duplications has changed their sequence for further roles as well as the sequences linked to this protein. Surprisingly, avian genomes lack this essential protein. Furthermore, mammalian evolution shows two different pathways for this protein leading to open questions about the functionality of the second sequence of fibrillarin.
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Why is it important?
This is relevant in several fields. Fibrillarin is required for Viral progression in plants and plays several roles in viral infection in humans and animals. Furthermore, the expression of fibrillarin and fibrillarin is different and increases in different types of cancers. It is currently unknown many of the aspects that this protein may play in all these illnesses, but its role is far from well understood.
Perspectives
Current research involves understanding other partners of this protein in human cell lines. This includes nonstandard guide RNA for this protein that may lead to either specific RNA methylation or RNA breaks. Non-nucleolar role of this protein and understanding the role of fibrillarin-like protein.
enrique castano
Read the Original
This page is a summary of: Fibrillarin evolution through the Tree of Life: Comparative genomics and microsynteny network analyses provide new insights into the evolutionary history of Fibrillarin, PLoS Computational Biology, October 2020, PLOS,
DOI: 10.1371/journal.pcbi.1008318.
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