What is it about?

The polyol pathway, once thought to be a glucose metabolic pathway with no significant function, has been found to play a key role in detecting glucose levels. This pathway senses the presence of glucose and communicates this information to the Mondo/ChREBP transcription factor, which then controls various metabolic enzymes to adjust glucose processing based on its availability.

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Why is it important?

When glucose levels are not sensed accurately, the cell's metabolic regulation can become disrupted, potentially leading to metabolic diseases like diabetes. Understanding how cells detect glucose can help us learn more about why these illnesses occur and how to address them effectively.


I'm curious about why the polyol pathway is particularly suited for sensing glucose. Investigating this question could provide insights into why this pathway, which isn't involved in producing energy or synthesizing biomolecules, has been conserved throughout evolution.

Hiroko Sano
Kurume University, Institute of Life Science

Read the Original

This page is a summary of: The polyol pathway is an evolutionarily conserved system for sensing glucose uptake, PLoS Biology, June 2022, PLOS,
DOI: 10.1371/journal.pbio.3001678.
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