What is it about?

Profhilo Structura, a newly launched injectable of Hybrid Cooperative Complex by IBSA Derma, was evaluated in a case study of a 54-year-old female presenting with skin laxity, volume loss, and fine lines, particularly in the mid and lower face. She sought a non-surgical solution to improve skin structure, hydration, and overall facial support while maintaining a natural appearance. The patient underwent two sessions of Profhilo Structura, spaced four weeks apart, using a fine cannula for precise product placement. This innovative injectable treatment combines high and low molecular weight hyaluronic acid (HA) to enhance hydration, stimulate collagen and elastin production, and provide structural support. Unlike traditional fillers, Profhilo Structura does not add volume but works within the superficial fat layers, promoting adipose tissue regeneration to restore youthful contours. At the four-week follow-up, the patient reported smoother, firmer, and more hydrated skin, with a noticeable softening of fine lines and improved facial definition. The treatment’s regenerative effects continued to enhance skin integrity, supporting long-term improvements in elasticity and structure. By restoring lost volume through adipose tissue remodeling, the results appeared natural, balanced, and rejuvenated without excessive product placement. This case highlights Profhilo Structura as a cutting-edge injectable treatment, aligning with the current focus on skin quality restoration and fat remodeling. By targeting subdermal layers, it provides a subtle yet effective rejuvenation, making it an excellent option for patients seeking long-term improvement in skin firmness, hydration, and structure.

Featured Image

Why is it important?

The introduction of Profhilo Structura comes at a time when the field of aesthetic medicine is shifting towards regenerative treatments that prioritise skin quality and structural support over traditional volumisation techniques. As patients increasingly seek natural-looking, non-surgical solutions, there is a growing demand for injectables that enhance the skin’s ability to repair and regenerate itself, rather than simply filling areas of volume loss. Aging is a multifactorial process involving collagen depletion, loss of skin elasticity, and fat atrophy, which contribute to sagging and loss of facial definition. While conventional dermal fillers effectively restore lost volume, they do not address the underlying structural changes that lead to these concerns. Profhilo Structura’s ability to regenerate adipose tissue and stimulate collagen and elastin production provides a more holistic approach to skin rejuvenation, improving both skin quality and soft tissue integrity. This injectable aligns with current trends in aesthetic medicine, where biostimulation and regenerative science are taking precedence over purely volumising approaches. As aesthetic clinicians seek treatments that support natural aging rather than masking it, Profhilo Structura offers an innovative solution that works at the dermal and subdermal levels to restore hydration, elasticity, and tissue integrity. Given the increasing preference for minimally invasive, long-lasting treatments, the ability of Profhilo Structura to support fat remodeling and improve skin structure makes it a timely and valuable addition to modern aesthetic practice, ensuring more sustainable and natural rejuvenation outcomes.

Perspectives

As an aesthetic practitioner and educator, I’ve seen a clear shift towards natural, regenerative treatments over traditional volumisation. Patients now prioritise skin quality, structure, and long-term improvement, making Profhilo Structura a timely and valuable innovation. From my experience, this injectable goes beyond hydration and volume replacement. By stimulating collagen and elastin and regenerating adipose tissue, it restores skin integrity and subtle facial support, creating a more natural and harmonious rejuvenation. Unlike conventional fillers, it enhances both dermal and subdermal structures, improving elasticity and hydration while preserving facial expression. Aging is more than volume loss—it’s skin laxity, fat redistribution, and structural decline. Profhilo Structura aligns with this modern understanding of aging, offering a minimally invasive, yet highly effective, way to restore skin health and facial balance. For me, this treatment represents the future of aesthetic medicine—a sophisticated, regenerative approach that enhances rather than alters. It’s a powerful tool in my practice, providing patients with a long-lasting, natural-looking solution to facial aging.

Jude Dunican

Read the Original

This page is a summary of: Profhilo Structura for skin rejuvenation, Journal of Aesthetic Nursing, January 2025, Mark Allen Group,
DOI: 10.12968/joan.2024.0054.
You can read the full text:

Read

Contributors

The following have contributed to this page