A sequence unique to high risk HPV, that it may confer the oncogenic potential of these strains

What is it about?

We identify a previously unnoticed insert near the 3’-end of the E6 oncoprotein gene in High risk HPV. We suggest that the exerts a dual effect, altering E6 protein as well as regulating E7 translation. This inserted sequence may account for the tumorigenic potential of High risk HPV.

Featured Image

Why is it important?

To the best of our knowledge, this is the only differentiating element between high risk and low risk HPV types. We suggest a dual mechanism by which the instead sequence account for the oncogenic potential of high-risk HPV types. Investigation of these may elucidate the HPV genome evolution that led to the carcinogenic potential of the some alpha-HPV type, that has been poorly understood so far.