What is it about?
Stem cells in the bone marrow supply precursors to bone and fat cells. Exercise increases bone and decreases fat. This involves cellular signals which are transferred from the cytoplasm into the nucleus.
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Why is it important?
• Growing evidence supports gene expression in multipotential stem cells is dependent on nuclear structure. • Nuclear structure is affected by connections transmitted from the cell membrane through actin to elements on the nuclear membrane. • Because actin is critical to the transfer of force into the nucleus -we hypothesize that transport of actin into the nucleus is critical to exercise control of stem cells.
Perspectives
Exercise control of stem cells is an active area of investigation. Elucidating these cellular signals enables the development of future therapies for bone fragility disorders, such as osteoporosis.
Dr Maya Styner
University of North Carolina at Chapel Hill, Department of Medicine, Division of Endocrinology
Read the Original
This page is a summary of: Physical Signals May Affect Mesenchymal Stem Cell Differentiation via Epigenetic Controls, Exercise and Sport Sciences Reviews, January 2018, Wolters Kluwer Health, DOI: 10.1249/jes.0000000000000129.
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