The Role of Matrix Metalloproteinase in Oral Squamous Cell Carcinoma

What is it about?

This chapter provides a comprehensive analysis of the molecular and cellular roles of matrix metalloproteinases (MMPs) in the pathogenesis and progression of oral squamous cell carcinoma (OSCC). It explores how MMPs contribute to key cancer-related processes, including extracellular matrix degradation, tumor invasion, angiogenesis, and metastasis. The study also examines regulatory mechanisms controlling MMP expression and activity, as well as the potential of MMPs as biomarkers for prognosis and as therapeutic targets. By integrating findings from experimental and clinical research, the paper offers insights into how MMPs drive OSCC progression and highlights future directions for translating this knowledge into improved diagnostic and treatment strategies.

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Photo by Shedrack Salami on Unsplash

Photo by Shedrack Salami on Unsplash

Why is it important?

Oral squamous cell carcinoma (OSCC) remains a major global health challenge due to its aggressive nature and poor prognosis, often linked to late diagnosis and limited therapeutic options. Understanding the role of matrix metalloproteinases (MMPs) in OSCC provides critical insights into the molecular mechanisms of tumor invasion, metastasis, and angiogenesis, which are key drivers of disease progression. This chapter is important because it consolidates current evidence on MMP involvement in OSCC and highlights their potential as biomarkers and therapeutic targets, paving the way for earlier detection and more effective, targeted treatments.

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