Aripiprazole in the Treatment of the Psychosis Prodrome

What is it about?

Research studies for the treatment of the putative prodromal phase of psychotic disorders have begun to appear. To obtain preliminary evidence of the short-term efficacy and safety of aripiprazole treatment in people with the psychosis prodrome. Fifteen participants meeting prodrome criteria enrolled in an open-label, single-site trial with fixed-flexible dosing of aripiprazole for 8 weeks. In the mixed-effects repeated-measures analysis, improvement from baseline on the Scale of Prodromal Symptoms total score was statistically significant by the first week. No participant converted to psychosis and 13 completed treatment. Neuropsychological measures showed no consistent improvement; mean weight gain was 1.2 kg. Akathisia emerged in 8 participants, but the mean Barnes Akathisia Scale score fell to baseline levels by the final visit. Adverse events were otherwise minimal

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Why is it important?

Aripiprazole shows a promising efficacy and safety profile for the psychosis prodrome. Placebo-controlled studies are indicated.