What is it about?

Dicoumarol, a coumarin-like compound, is known for its anticoagulant properties associated with the ability to inhibit vitamin K, being prescribed as a drug for several decades. The pharmaceutical value of dicoumarol turned it into a focus of chemists’ attention, aiming its synthesis and of dicoumarol derivatives, bringing to light new methodologies.

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Why is it important?

In recent years, several other bioactive effects have been claimed for dicoumarol and its derivatives, including anti-inflammatory, antimicrobial, antifungal, and anticancer, although the mechanisms of action underlying them are mostly not disclosed and additional research is needed to unravel them.


This review presents a state of the art on the chemistry of dicoumarols, and their potential anticancer characteristics, highlighting the mechanisms of action elucidated so far. In parallel, we draw attention to the lack of in vivo studies and clinical trials to assess the safety and efficacy as drugs for later application.

habilitated doctor, chemist Monica BUTNARIU
University of Life Sciences "King Mihai I" from Timisoara

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This page is a summary of: Dicoumarol: from chemistry to antitumor benefits, Chinese Medicine, December 2022, Springer Science + Business Media,
DOI: 10.1186/s13020-022-00699-0.
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