What is it about?

Cancer is the second most killer worldwide causing millions of people to lose their lives every year. In the case of women, breast cancer takes away the highest proportion of mortality rate than other cancers.

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Why is it important?

New effective therapeutic compounds and treatment method is the best way to look out for in this critical time. For instance, new synthetic derivatives/ analogues synthesized from different compounds can be a ray of hope. Numerous synthetic compounds have been seen enhancing the apoptosis and autophagic pathway that directly exerts cytotoxicity towards different breast cancer cell lines.


This review aims to identify the anti‑breast cancer properties of several synthetic derivatives against different breast cancer and multi‑drug‑resistant breast cancer cell lines with their reported mechanism of action and effectivity.

habilitated doctor, chemist Monica BUTNARIU
University of Life Sciences "King Mihai I" from Timisoara

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This page is a summary of: Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study, Cancer Cell International, November 2021, Springer Science + Business Media, DOI: 10.1186/s12935-021-02309-9.
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