What is it about?
Endothelial cells are the primary targets of heparin-binding protein (HBP) released in the circulation and this protein plays a major role in the mechanism of capillary leakage, while it amplifies inflammatory effects. This study aimed to examine the relevance of the novel inflammatory factor HBP in critically ill COVID-19 patients, and evaluate the correlation of the biomarker with disease progression.
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Why is it important?
For the first time, this study found that HBP levels were associated with COVID-19 disease progression in critically ill patients.
Perspectives
As a potential mediator of disease aggravation and multiple organ injuries that are triggered by continuing inflammation and oxygen deficits, HBP warrants further study as a disease biomarker and potential therapeutic target.
Dr. Hui-Qi Qu
Children's Hospital of Philadelphia
Read the Original
This page is a summary of: Heparin-binding protein levels correlate with aggravation and multiorgan damage in severe COVID-19, ERJ Open Research, November 2020, European Respiratory Society (ERS),
DOI: 10.1183/23120541.00741-2020.
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