What is it about?
We have studied redox activity of iron(III) complexes (pentadentate amino-phenol complexes, EHPG and EHBG / HBED ) in Fenton reaction and Haber-Weiss cycle.
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Why is it important?
Iron(III) complexes could serve as MRI contrast agents. On of the main thread is their undesired, potential redox activity leading to the formation of reactive oxygen species (ROS). We have studies shown that redox activity of the iron(III) complexes (MRI contrast candidates) is 20% of the most active [FeEDTA]- complex. This limits their deleterious effects upon clinical administration.
Perspectives
The results drive the attractiveness of iron(III) complexes as MRI contrast agents.
Dr Nikodem Kuźnik
Silesian University of Technology
Read the Original
This page is a summary of: Studies on the redox activity of iron N,O-complexes: Potential T1-contrast agents, Redox Report, January 2016, Taylor & Francis,
DOI: 10.1179/1351000215y.0000000017.
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