PAX8 is a highly sensitive marker for glands of endometriosis.

What is it about?

For better accuracy of diagnosis for endometriosis, the development of a sensitive and specific epithelial marker is beneficial. Now, we sought to examine whether PAX8 is a highly sensitive marker for glands in extra-genital endometriosis.

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Why is it important?

In cases of extragenital endometriosis or microscopic endometriosis lesions, pathological diagnosis can be challenging, because endometriotic stroma and glands represent only a minor component of fibrotic endometriotic lesions. This study shows that PAX8 is a highly sensitive epithelial marker for extragenital endometriosis. This specific expression was maintained under hormonal therapy. PAX8 nuclear expression is useful in detecting extragenital endometriosis in clinical practice.

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