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  1. The histone methyltransferase KMT2D is essential for embryo implantation via regulating precise differentiation of endometrial cells

    Article • Cell Death Discovery, August 2024, Springer Science + Business Media

    Professor Yasushi Hirota

  2. Spatial and molecular anatomy of the endometrium during embryo implantation: a current overview of key regulators of blastocyst invasion

    Article • European Journal of Biochemistry, February 2024, Wiley

    Professor Yasushi Hirota

  3. Roles of lipid mediators in early pregnancy events

    Article • Reproductive Medicine and Biology, January 2024, Wiley

    Professor Yasushi Hirota

  4. Current perspectives on endometrial receptivity: A comprehensive overview of etiology and treatment

    Article • Journal of Obstetrics and Gynaecology Research, August 2023, Wiley

    Professor Yasushi Hirota

  5. Differences in the incidence of obstetric complications depending on the extent and location of adenomyosis lesions

    Article • The Journal of Maternal-Fetal & Neonatal Medicine, June 2023, Taylor & Francis

    Professor Yasushi Hirota

  6. The EZH2–PRC2–H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion

    Article • Cell Death and Disease, May 2023, Springer Science + Business Media

    Professor Yasushi Hirota

  7. How does adenomyosis impact endometrial receptivity? An updated systematic review of clinical and molecular insights

    Article • F&S Reviews, January 2023, Elsevier

    Professor Yasushi Hirota

  8. Establishment of a novel mouse model of adenomyosis suitable for longitudinal and quantitative analysis and perinatal outcome studies

    Article • Scientific Reports, October 2022, Springer Science + Business Media

    Professor Yasushi Hirota

  9. Impact of Chronic Exposure to Endometriosis on Perinatal Outcomes: Establishment of a Mouse Model

    Article • Biomedicines, October 2022, MDPI AG

    Professor Yasushi Hirota

  10. Levonorgestrel-Releasing Intrauterine System Improves Menorrhagia-Related Quality of Life in Patients with Symptomatic Adenomyosis

    Article • Reproductive Sciences, September 2022, Springer Science + Business Media

    Professor Yasushi Hirota

  11. Notch Signaling Induced by Endoplasmic Reticulum Stress Regulates Cumulus-Oocyte Complex Expansion in Polycystic Ovary Syndrome

    Article • Biomolecules, July 2022, MDPI AG

    Professor Yasushi Hirota

  12. Long-term conservative management of symptomatic bladder endometriosis: A case series of 17 patients

    Article • Taiwanese Journal of Obstetrics and Gynecology, July 2022, Elsevier

    Professor Yasushi Hirota

  13. DNA Methylation and Histone Modification Are the Possible Regulators of Preimplantation Blastocyst Activation in Mice

    Article • Reproductive Sciences, May 2022, Springer Science + Business Media

    Professor Yasushi Hirota

  14. Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females

    Article • Endocrinology, April 2022, Endocrine Society

    Professor Yasushi Hirota

  15. Adenomyosis in Reproductive Years: Abnormal Uterine Bleeding and Pain

    Article • January 2022, Springer Science + Business Media

    Professor Yasushi Hirota

  16. A gene network of uterine luminal epithelium organizes mouse blastocyst implantation

    Article • Reproductive Medicine and Biology, January 2022, Wiley

    Professor Yasushi Hirota

  17. Guidelines for Reproductive Medicine in Japan

    Article • Reproductive Medicine and Biology, January 2022, Wiley

    Professor Yasushi Hirota

  18. Prediction of the final menstrual period in women taking Dienogest using estradiol and follicle-stimulating hormone values: a case-control study

    Article • Endocrine Journal, January 2022, Japan Endocrine Society

    Professor Yasushi Hirota

  19. Uterine Receptivity is Reflected by LIF Expression in the Cervix

    Article • Reproductive Sciences, December 2021, Springer Science + Business Media

    Professor Yasushi Hirota

  20. The roles of polymorphonuclear myeloid-derived suppressor cells in endometriosis

    Article • Journal of Reproductive Immunology, November 2021, Elsevier

    Professor Yasushi Hirota

  21. The roles of polymorphonuclear myeloid-derived suppressor cells in endometriosis patients

    Article • Journal of Reproductive Immunology, November 2021, Elsevier

    Professor Yasushi Hirota

  22. Temporal relationship between alterations in the gut microbiome and the development of polycystic ovary syndrome‐like phenotypes in prenatally androgenized female mice

    Article • The FASEB Journal, October 2021, Wiley

    Professor Yasushi Hirota

  23. Uterine Epithelial LIF Receptors Contribute to Implantation Chamber Formation in Blastocyst Attachment

    Article • Endocrinology, August 2021, Endocrine Society

    Professor Yasushi Hirota

  24. Unbiased, comprehensive analysis of Japanese health checkup data reveals a protective effect of light to moderate alcohol consumption on lung function

    Article • Scientific Reports, August 2021, Springer Science + Business Media

    Professor Yasushi Hirota

  25. Automated system for diagnosing endometrial cancer by adopting deep-learning technology in hysteroscopy

    Article • PLOS One, March 2021, PLOS

    Professor Yasushi Hirota

  26. Induction of aryl hydrocarbon receptor in granulosa cells by endoplasmic reticulum stress contributes to pathology of polycystic ovary syndrome

    Article • Molecular Human Reproduction, January 2021, Oxford University Press (OUP)

    Professor Yasushi Hirota

  27. CD206+ macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model

    Article • Scientific Reports, January 2021, Springer Science + Business Media

    Professor Yasushi Hirota

  28. Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion

    Article • EMBO Reports, January 2021, Springer Science + Business Media

    Professor Yasushi Hirota

  29. Ovarian reserve may influence the outcome of bone mineral density in patients with long-term use of dienogest

    Article • SAGE Open Medicine, January 2021, SAGE Publications

    Professor Yasushi Hirota

  30. Use of selective PGE2 receptor antagonists on human endometriotic stromal cells and peritoneal macrophages

    Article • Molecular Human Reproduction, January 2021, Oxford University Press (OUP)

    Professor Yasushi Hirota

  31. Uterine Epithelial Progesterone Receptor Governs Uterine Receptivity Through Epithelial Cell Differentiation

    Article • Endocrinology, October 2020, Endocrine Society

    Professor Yasushi Hirota, Professor Osama Fekry Al Balah

  32. CD206+ M2-Like Macrophages Are Essential for Successful Implantation

    Article • Frontiers in Immunology, October 2020, Frontiers

    Professor Yasushi Hirota

  33. A case of hemorrhagic shock occurred during dienogest therapy for uterine adenomyosis

    Article • Journal of Obstetrics and Gynaecology Research, October 2020, Wiley

    Professor Yasushi Hirota

  34. Differential roles of uterine epithelial and stromal STAT3 coordinate uterine receptivity and embryo attachment

    Article • Scientific Reports, September 2020, Springer Science + Business Media

    Professor Yasushi Hirota

  35. Prolapse of a pedunculated uterine leiomyoma through the cervix during GnRH antagonist treatment: Case report and literature review

    Article • Journal of Obstetrics and Gynaecology Research, September 2020, Wiley

    Chihiro Ishizawa, Professor Yasushi Hirota

  36. Acquired contractile ability in human endometrial stromal cells by passive loading of cyclic tensile stretch

    Article • Scientific Reports, June 2020, Springer Science + Business Media

    Professor Yasushi Hirota

  37. The effects of tokishakuyakusan, a traditional Japanese medicine (kampo), ferulic acid and paeoniflorin, on human endometriotic stromal cells and peritoneal macrophages

    Article • Journal of Reproductive Immunology, June 2020, Elsevier

    Professor Yasushi Hirota

  38. KRAS mutations in uterine endometrium are associated with gravidity and parity

    Article • Cell Death and Disease, May 2020, Springer Science + Business Media

    Professor Yasushi Hirota

  39. Androgens Increase Accumulation of Advanced Glycation End Products in Granulosa Cells by Activating ER Stress in PCOS

    Article • Endocrinology, February 2020, Endocrine Society

    Professor Yasushi Hirota

  40. Niclosamide suppresses macrophage-induced inflammation in endometriosis†

    Article • Biology of Reproduction, January 2020, Oxford University Press (OUP)

    Professor Yasushi Hirota

  41. Dienogest suppresses cellular proliferation status of endometrial polyps and acts differently depending on the morphological type

    Article • Women s Health, January 2020, SAGE Publications

    Professor Yasushi Hirota

  42. Expression of ALDH1A Isozymes in Human Endometrium with and without Endometriosis and in Ovarian Endometrioma

    Article • Reproductive Sciences, January 2020, Springer Science + Business Media

    Professor Yasushi Hirota

  43. Activation of endoplasmic reticulum stress mediates oxidative stress–induced apoptosis of granulosa cells in ovaries affected by endometrioma

    Article • Molecular Human Reproduction, December 2019, Oxford University Press (OUP)

    Professor Yasushi Hirota

  44. Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations

    Article • Nature Communications, December 2019, Springer Science + Business Media

    Professor Yasushi Hirota

  45. A survey of public attitudes toward uterus transplantation, surrogacy, and adoption in Japan

    Article • PLOS One, October 2019, PLOS

    tetsuya hirata, Professor Yasushi Hirota

  46. Levonorgestrel Inhibits Embryo Attachment by Eliminating Uterine Induction of Leukemia Inhibitory Factor

    Article • Endocrinology, October 2019, Endocrine Society

    Professor Yasushi Hirota

  47. Accumulation of advanced glycation end products in follicles is associated with poor oocyte developmental competence

    Article • Molecular Human Reproduction, August 2019, Oxford University Press (OUP)

    Professor Yasushi Hirota

  48. Placental expression of lysophosphatidic acid receptors in normal pregnancy and preeclampsia

    Article • American Journal of Reproductive Immunology, August 2019, Wiley

    Professor Yasushi Hirota

  49. Clinical aspects and management of inguinal endometriosis: A case series of 20 patients

    Article • Journal of Obstetrics and Gynaecology Research, August 2019, Wiley

    Professor Yasushi Hirota

  50. Cell Cycle Perturbation Induces Collagen Production in Fibroblasts

    Article • International Heart Journal, July 2019, International Heart Journal (Japanese Heart Journal)

    Professor Yasushi Hirota

  51. Role of oxidative stress in follicular fluid on embryos of patients undergoing assisted reproductive technology treatment

    Article • Journal of Obstetrics and Gynaecology Research, July 2019, Wiley

    Professor Yasushi Hirota

  52. Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M

    Article • Nature Communications, June 2019, Springer Science + Business Media

    Professor Yasushi Hirota

  53. Endometriosis Triggers Excessive Activation of Primordial Follicles via PI3K-PTEN-Akt-Foxo3 Pathway

    Article • The Journal of Clinical Endocrinology & Metabolism, June 2019, Endocrine Society

    Professor Yasushi Hirota

  54. Uterine receptivity, embryo attachment, and embryo invasion: Multistep processes in embryo implantation

    Article • Reproductive Medicine and Biology, May 2019, Wiley

    Professor Yasushi Hirota

  55. Contralateral ovarian endometrioma recurrence after unilateral salpingo-oophorectomy

    Article • BMC Women s Health, May 2019, Springer Science + Business Media

    Professor Yasushi Hirota

  56. Endothelial Cells in the Decidual Bed Are Potential Therapeutic Targets for Preterm Birth Prevention

    Article • Cell Reports, May 2019, Elsevier

    Professor Yasushi Hirota

  57. IFITM1 is a Novel, Highly Sensitive Marker for Endometriotic Stromal Cells in Ovarian and Extragenital Endometriosis

    Article • Reproductive Sciences, February 2019, SAGE Publications

    tetsuya hirata, Professor Yasushi Hirota

  58. PAX8 is a highly sensitive marker for glands of endometriosis.

    Article • Reproductive Sciences, February 2019, SAGE Publications

    tetsuya hirata, Professor Yasushi Hirota

  59. Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary

    Article • Reproductive Biology and Endocrinology, February 2019, Springer Science + Business Media

    Professor Yasushi Hirota

  60. Mdm2-p53-SF1 pathway in ovarian granulosa cells directs ovulation and fertilization by conditioning oocyte quality

    Article • The FASEB Journal, February 2019, Federation of American Societies For Experimental Biology (FASEB)

    Professor Yasushi Hirota, tetsuya hirata, Hirofumi Haraguchi

  61. Progesterone governs endometrial proliferation-differentiation switching and blastocyst implantation

    Article • Endocrine Journal, January 2019, Japan Endocrine Society

    Professor Yasushi Hirota

  62. Endoplasmic Reticulum Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS

    Article • Endocrinology, November 2018, Endocrine Society

    Professor Yasushi Hirota

  63. A survey of public attitudes towards third-party reproduction in Japan in 2014

    Article • PLOS One, October 2018, PLOS

    Professor Yasushi Hirota

  64. Expression of Nerve Injury-Induced Protein1 (Ninj1) in Endometriosis

    Article • Reproductive Sciences, October 2018, SAGE Publications

    Professor Yasushi Hirota

  65. The efficacy of non-assisted reproductive technology treatment might be limited in infertile patients with advanced endometriosis in their 30s

    Article • Journal of Obstetrics and Gynaecology Research, October 2018, Wiley

    Professor Yasushi Hirota

  66. Activation of Nrf2 might reduce oxidative stress in human granulosa cells

    Article • Molecular and Cellular Endocrinology, July 2018, Elsevier

    Professor Yasushi Hirota

  67. HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment

    Article • Journal of Clinical Investigation, June 2018, American Society for Clinical Investigation

    Professor Yasushi Hirota

  68. Thoracic endometriosis syndrome: Comparison between catamenial pneumothorax or endometriosis-related pneumothorax and catamenial hemoptysis

    Article • European Journal of Obstetrics & Gynecology and Reproductive Biology, June 2018, Elsevier

    Professor Yasushi Hirota

  69. Long-term dienogest administration in patients with symptomatic adenomyosis

    Article • Journal of Obstetrics and Gynaecology Research, May 2018, Wiley

    Professor Yasushi Hirota

  70. A survey of public attitudes towards third-party reproduction in Japan in 2014

    Article • May 2018, Cold Spring Harbor Laboratory Press

    Professor Yasushi Hirota

  71. Adenomyosis and Subfertility

    Article • January 2018, Springer Science + Business Media

    Professor Yasushi Hirota

  72. Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis

    Article • Scientific Reports, September 2017, Springer Science + Business Media

    Professor Yasushi Hirota

  73. Nomenclature of primary amenorrhea: A proposal document of the Japan Society of Obstetrics and Gynecology committee for the redefinition of primary amenorrhea

    Article • Journal of Obstetrics and Gynaecology Research, August 2017, Wiley

    Dr HIdeya Sakakibara, Professor Yasushi Hirota

  74. Autotaxin–lysophosphatidic acid–LPA 3 signaling at the embryo‐epithelial boundary controls decidualization pathways

    Article • The EMBO Journal, June 2017, EMBO

    Professor Yasushi Hirota

  75. F4/80+ Macrophages Contribute to Clearance of Senescent Cells in the Mouse Postpartum Uterus

    Article • Endocrinology, May 2017, Endocrine Society

    Professor Yasushi Hirota, Hirofumi Haraguchi

  76. Oil-Soluble Contrast Medium (OSCM) for Hysterosalpingography Modulates Dendritic Cell and Regulatory T Cell Profiles in the Peritoneal Cavity: A Possible Mechanism by Which OSCM Enhances Fertility

    Article • The Journal of Immunology, April 2017, The American Association of Immunologists

    Professor Yasushi Hirota

  77. Preoperative assessment of factors associated with difficulty in performing total laparoscopic hysterectomy

    Article • Journal of Obstetrics and Gynaecology Research, February 2017, Wiley

    Professor Yasushi Hirota

  78. Drospirenone reduces inflammatory cytokines, vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) expression in human endometriotic stromal cells

    Article • Journal of Reproductive Immunology, February 2017, Elsevier

    Professor Yasushi Hirota

  79. Mannose receptor is highly expressed by peritoneal dendritic cells in endometriosis

    Article • Fertility and Sterility, January 2017, Elsevier

    Professor Yasushi Hirota

  80. Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis

    Article • European Journal of Obstetrics & Gynecology and Reproductive Biology, December 2016, Elsevier

    Professor Yasushi Hirota

  81. a potential role for endoplasmic reticulum stress

    Article • Endocrinology, November 2016, Endocrine Society

    Professor Yasushi Hirota, Nozomi Takahashi, tetsuya hirata

  82. Development of ovarian cancer after excision of endometrioma

    Article • Fertility and Sterility, November 2016, Elsevier

    Professor Yasushi Hirota

  83. p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing

    Article • Journal of Clinical Investigation, July 2016, American Society for Clinical Investigation

    Professor Yasushi Hirota

  84. Neutrophil depletion reduces endometriotic lesion formation in mice

    Article • American Journal of Reproductive Immunology, July 2016, Wiley

    Professor Yasushi Hirota

  85. Role of STAT3 in endometrial regeneration in the mouse model of decellularized uterine matrix transplantation

    Article • June 2016, Morressier

    Professor Yasushi Hirota

  86. Reduced homeobox protein MSX1 in human endometrial tissue is linked to infertility

    Article • Human Reproduction, June 2016, Oxford University Press (OUP)

    Professor Yasushi Hirota

  87. STAT3 accelerates uterine epithelial regeneration in a mouse model of decellularized uterine matrix transplantation

    Article • JCI Insight, June 2016, American Society for Clinical Investigation

    Professor Yasushi Hirota

  88. A potential role of endoplasmic reticulum stress in development of ovarian hyperstimulation syndrome

    Article • Molecular and Cellular Endocrinology, June 2016, Elsevier

    Nozomi Takahashi, Professor Yasushi Hirota

  89. Effects of 1,25-Dihydroxy Vitamin D3 on Endometriosis

    Article • The Journal of Clinical Endocrinology & Metabolism, June 2016, Endocrine Society

    Professor Yasushi Hirota

  90. Dienogest reduces nerve growth factor expression in human adenomyosis

    Article • Journal of Reproductive Immunology, June 2016, Elsevier

    Professor Yasushi Hirota

  91. Effects of omega-3 fatty acids on Nod-like receptor 3 (NLRP3) inflammasome in decidual macrophages

    Article • Journal of Reproductive Immunology, June 2016, Elsevier

    Professor Yasushi Hirota

  92. Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells

    Article • American Journal of Reproductive Immunology, January 2016, Wiley

    Professor Yasushi Hirota

  93. Th2 cells and Th17 cells in the development of endometriosis – possible roles of interleukin-4 and interleukin-17A

    Article • Journal of Endometriosis, January 2016, SAGE Publications

    Professor Yasushi Hirota

  94. Uterine Cellular Senescence in the Mouse Model of Preterm Birth

    Article • January 2016, Springer Science + Business Media

    Professor Yasushi Hirota

  95. Uterine Receptivity in Mouse Embryo Implantation

    Article • January 2016, Springer Science + Business Media

    Professor Yasushi Hirota

  96. Crucial role of hypoxia inducible factor in embryo implantation

    Article • Journal of Reproductive Immunology, November 2015, Elsevier

    Professor Yasushi Hirota

  97. How does Progesterone Support Embryo Implantation?

    Article • Journal of Mammalian Ova Research, October 2015, Japanese Society of Mammalian Ova Research

    Professor Yasushi Hirota

  98. Simultaneous Detection and Evaluation of Four Subsets of CD4+ T Lymphocyte in Lesions and Peripheral Blood in Endometriosis

    Article • American Journal of Reproductive Immunology, September 2015, Wiley

    Professor Yasushi Hirota

  99. Four Cases of Postoperative Pneumothorax Among 2814 Consecutive Laparoscopic Gynecologic Surgeries: A Possible Correlation Between Postoperative Pneumothorax and Endometriosis

    Article • Journal of Minimally Invasive Gynecology, September 2015, Elsevier

    Professor Yasushi Hirota

  100. Evidence of the activation of unfolded protein response in granulosa and cumulus cells during follicular growth and maturation

    Article • Gynecological Endocrinology, August 2015, Informa Healthcare

    Nozomi Takahashi, Professor Yasushi Hirota

  101. The impact of elevated thyroid stimulating hormone on female subfertility

    Article • Reproductive Medicine and Biology, August 2015, Wiley

    Professor Yasushi Hirota

  102. Drospirenone induces decidualization in human eutopic endometrial stromal cells and reduces DNA synthesis of human endometriotic stromal cells

    Article • Fertility and Sterility, July 2015, Elsevier

    Professor Yasushi Hirota

  103. Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus

    Article • Journal of Biological Chemistry, April 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Yasushi Hirota

  104. Cyclic Stretch Augments Production of Neutrophil Chemokines, Matrix Metalloproteinases, and Activin A in Human Endometrial Stromal Cells

    Article • American Journal of Reproductive Immunology, January 2015, Wiley

    Professor Yasushi Hirota

  105. Interleukin-1β increases expression of tryptophan 2,3-dioxygenase and stimulates tryptophan metabolism in ectopic endomtetrial stromal cells

    Article • Journal of Reproductive Immunology, December 2014, Elsevier

    Professor Yasushi Hirota

  106. Pathophysiological role of cellular senescence in the mouse postpartum endometrium

    Article • Journal of Reproductive Immunology, December 2014, Elsevier

    Professor Yasushi Hirota

  107. The serum level of vitamin D of endometriosis patients

    Article • Journal of Reproductive Immunology, December 2014, Elsevier

    Professor Yasushi Hirota

  108. Application of Detergents or High Hydrostatic Pressure as Decellularization Processes in Uterine Tissues and Their Subsequent Effects on In Vivo Uterine Regeneration in Murine Models

    Article • PLOS One, July 2014, PLOS

    Professor Yasushi Hirota

  109. MicroRNA-200a Locally Attenuates Progesterone Signaling in the Cervix, Preventing Embryo Implantation

    Article • Molecular Endocrinology, July 2014, Endocrine Society

    Professor Yasushi Hirota

  110. IL-1β Increases Expression of Tryptophan 2,3-dioxygenase and Stimulates Tryptophan Catabolism in Endometrioma Stromal Cells

    Article • American Journal of Reproductive Immunology, June 2014, Wiley

    Professor Yasushi Hirota

  111. Efficacy of dienogest in the treatment of symptomatic adenomyosis: a pilot study

    Article • Gynecological Endocrinology, June 2014, Taylor & Francis

    Professor Yasushi Hirota

  112. Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis

    Article • Gynecological Endocrinology, May 2014, Taylor & Francis

    Professor Yasushi Hirota

  113. The Role of Bone Morphogenetic Protein 6 in Accumulation and Regulation of Neutrophils in the Human Ovary

    Article • Reproductive Sciences, January 2014, SAGE Publications

    Professor Yasushi Hirota

  114. Endometrial cellular senescence contributes to preterm birth

    Article • Inflammation and Regeneration, January 2014, Japanese Society of Inflammation and Regeneration

    Professor Yasushi Hirota

  115. Infertility Treatment of Endometriosis Patients

    Article • January 2014, Springer Science + Business Media

    Professor Yasushi Hirota

  116. Bone Morphogenetic Protein 7 Increased Vascular Endothelial Growth Factor (VEGF)-A Expression in Human Granulosa Cells and VEGF Receptor Expression in Endothelial Cells

    Article • Reproductive Sciences, September 2013, Springer Science + Business Media

    Professor Yasushi Hirota

  117. Interleukin-1beta increases expression of tryptophan 2,3-dioxygenase and stimulates tryptophan metabolism in ectopic endometrial stromal cells

    Article • Fertility and Sterility, September 2013, Elsevier

    Professor Yasushi Hirota

  118. Gene-environment interactions underlie preterm birth

    Article • Fertility and Sterility, September 2013, Elsevier

    Professor Yasushi Hirota

  119. Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions

    Article • Journal of Clinical Investigation, August 2013, American Society for Clinical Investigation

    Professor Yasushi Hirota

  120. Uterine receptivity and embryo-uterine interactions in embryo implantation: lessons from mice

    Article • Reproductive Medicine and Biology, June 2013, Wiley

    Professor Yasushi Hirota

  121. Interleukin-4 and Prostaglandin E2 Synergistically Up-Regulate 3β-Hydroxysteroid Dehydrogenase Type 2 in Endometrioma Stromal Cells

    Article • The Journal of Clinical Endocrinology & Metabolism, April 2013, Endocrine Society

    Professor Yasushi Hirota

  122. Cyclic Stretch Augments Production of Neutrophil Chemokines and Matrix Metalloproteinases-1 (MMP-1) from Human Decidual Cells, and the Production was Reduced by Progesterone

    Article • American Journal of Reproductive Immunology, February 2013, Wiley

    Professor Yasushi Hirota

  123. Cyclic Stretch Augments Production of Neutrophil Chemokines and Matrix Metalloproteinase-1 in Human Uterine Smooth Muscle Cells

    Article • American Journal of Reproductive Immunology, December 2012, Wiley

    Professor Yasushi Hirota

  124. Follistatin Is Induced by IL-1β and TNF-α in Stromal Cells From Endometrioma

    Article • Reproductive Sciences, November 2012, Springer Science + Business Media

    Professor Yasushi Hirota

  125. Estrogen-Dependent Uterine Secretion of Osteopontin Activates Blastocyst Adhesion Competence

    Article • PLOS One, November 2012, PLOS

    Professor Yasushi Hirota

  126. Interleukin-17A is present in neutrophils in endometrioma and stimulates the secretion of growth-regulated oncogene–α (Gro-α) from endometrioma stromal cells

    Article • Fertility and Sterility, November 2012, Elsevier

    Professor Yasushi Hirota

  127. Thrombin enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts; possible involvement in the pathogenesis of preeclampsia

    Article • Fertility and Sterility, October 2012, Elsevier

    Professor Yasushi Hirota

  128. Uterine Deletion ofTrp53Compromises Antioxidant Responses in the Mouse Decidua

    Article • Endocrinology, September 2012, Endocrine Society

    Professor Yasushi Hirota

  129. The Localization and Regulation of Proprotein Convertase Subtilisin/Kexin (PCSK) 6 in Human Ovary

    Article • American Journal of Reproductive Immunology, August 2012, Wiley

    Professor Yasushi Hirota

  130. Interleukin-1β stimulates the secretion of thymic stromal lymphopoietin (TSLP) from endometrioma stromal cells: possible involvement of TSLP in endometriosis

    Article • Human Reproduction, August 2012, Oxford University Press (OUP)

    Professor Yasushi Hirota

  131. Galectin-1 Markedly Reduces the Incidence of Resorptions in Mice Missing Immunophilin FKBP52

    Article • Endocrinology, May 2012, Endocrine Society

    Professor Yasushi Hirota

  132. Sensing senescence in preterm birth

    Article • Cell Cycle, January 2012, Taylor & Francis

    Professor Yasushi Hirota

  133. Proteinase-activated receptors in the endometrium and endometriosis

    Article • January 2012, Frontiers in Bioscience

    Professor Yasushi Hirota

  134. Endometriosis May Be Promoted by Midkine: Possible Involvement of Ovarian Follicles

    Article • January 2012, Springer Science + Business Media

    Professor Yasushi Hirota

  135. Proteinase-activated receptors in the endometrium and endometriosis

    Article • Frontiers in Bioscience-Elite, January 2012, IMR Press

    Professor Yasushi Hirota

  136. Toll-Like Receptor-3 Ligation-Induced Indoleamine 2, 3-Dioxygenase Expression in Human Trophoblasts

    Article • Endocrinology, December 2011, Endocrine Society

    Professor Yasushi Hirota

  137. Conditional Deletion of MSX Homeobox Genes in the Uterus Inhibits Blastocyst Implantation by Altering Uterine Receptivity

    Article • Developmental Cell, December 2011, Elsevier

    Professor Yasushi Hirota

  138. Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice

    Article • Proceedings of the National Academy of Sciences, October 2011, Proceedings of the National Academy of Sciences

    Professor Yasushi Hirota

  139. Interleukin-17F increases the secretion of interleukin-8 and the expression of cyclooxygenase 2 in endometriosis

    Article • Fertility and Sterility, July 2011, Elsevier

    Professor Yasushi Hirota

  140. Activin-A is induced by interleukin-1β and tumor necrosis factor-α and enhances the mRNA expression of interleukin-6 and protease-activated receptor-2 and proliferation of stromal cells from endometrioma

    Article • Fertility and Sterility, July 2011, Elsevier

    Professor Yasushi Hirota

  141. TGF- 1 induces proteinase-activated receptor 2 (PAR2) expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6

    Article • Human Reproduction, May 2011, Oxford University Press (OUP)

    Professor Yasushi Hirota

  142. High Mobility Group Box 1 (HMGB1) Levels in the Placenta and in Serum in Preeclampsia

    Article • American Journal of Reproductive Immunology, January 2011, Wiley

    Professor Yasushi Hirota

  143. Lymphocytes in Endometriosis

    Article • American Journal of Reproductive Immunology, December 2010, Wiley

    Professor Yasushi Hirota

  144. Recruitment of CCR6-Expressing Th17 Cells by CCL 20 Secreted from IL-1β-, TNF-α-, and IL-17A-Stimulated Endometriotic Stromal Cells

    Article • Endocrinology, November 2010, Endocrine Society

    Professor Yasushi Hirota

  145. Bone Morphogenetic Protein-2 (BMP-2) Increases Gene Expression of FSH Receptor and Aromatase and Decreases Gene Expression of LH Receptor and StAR in Human Granulosa Cells

    Article • American Journal of Reproductive Immunology, September 2010, Wiley

    Professor Yasushi Hirota

  146. Uterine FK506-binding protein 52 (FKBP52)–peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress

    Article • Proceedings of the National Academy of Sciences, August 2010, Proceedings of the National Academy of Sciences

    Professor Yasushi Hirota

  147. Interleukin-4 induces expression of eotaxin in endometriotic stromal cells

    Article • Fertility and Sterility, June 2010, Elsevier

    Professor Yasushi Hirota

  148. Elevated serum soluble fms-like tyrosine kinase 1 (sFlt1) level in women with hydatidiform mole

    Article • Fertility and Sterility, June 2010, Elsevier

    Professor Yasushi Hirota

  149. Revisiting Reproduction: Prematurity and the puzzle of progesterone resistance

    Article • Nature Medicine, May 2010, Springer Science + Business Media

    Professor Yasushi Hirota

  150. Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice

    Article • Journal of Clinical Investigation, March 2010, American Society for Clinical Investigation

    Professor Yasushi Hirota

  151. Progesterone decreases bone morphogenetic protein (BMP) 7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells

    Article • Human Reproduction, January 2010, Oxford University Press (OUP)

    Professor Yasushi Hirota

  152. Bone morphogenetic protein-6 stimulates gene expression of follicle-stimulating hormone receptor, inhibin/activin β subunits, and anti-Müllerian hormone in human granulosa cells

    Article • Fertility and Sterility, November 2009, Elsevier

    Professor Yasushi Hirota

  153. Post-operative oral contraceptive use reduces the risk of ovarian endometrioma recurrence after laparoscopic excision

    Article • Human Reproduction, August 2009, Oxford University Press (OUP)

    Professor Yasushi Hirota

  154. Expression and possible implication of growth hormone–releasing hormone receptor splice variant 1 in endometriosis

    Article • Fertility and Sterility, July 2009, Elsevier

    Professor Yasushi Hirota

  155. TGF-Beta Increases Proteinase-Activated Receptor 2 (PAR2) Expression and Upregulates PAR2 Activation-Induced Secretion of IL-6 and IL-8 in Endometriotic Stromal Cells.

    Article • Biology of Reproduction, July 2009, Oxford University Press (OUP)

    Professor Yasushi Hirota

  156. Tunicamycin enhances the apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand in endometriotic stromal cells

    Article • Human Reproduction, February 2009, Oxford University Press (OUP)

    Professor Yasushi Hirota

  157. Interleukin (IL)-1β Stimulates Migration and Survival of First-Trimester Villous Cytotrophoblast Cells through Endometrial Epithelial Cell-Derived IL-8

    Article • Endocrinology, January 2009, Endocrine Society

    Professor Yasushi Hirota

  158. Deficiency of Immunophilin FKBP52 Promotes Endometriosis

    Article • American Journal Of Pathology, December 2008, Elsevier

    Professor Yasushi Hirota

  159. Interleukin-4 Stimulates Proliferation of Endometriotic Stromal Cells

    Article • American Journal Of Pathology, August 2008, Elsevier

    Professor Yasushi Hirota

  160. Conditional Loss of Uterine Pten Unfailingly and Rapidly Induces Endometrial Cancer in Mice

    Article • Cancer Research, July 2008, American Association for Cancer Research (AACR)

    Professor Yasushi Hirota

  161. Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells

    Article • Fertility and Sterility, May 2008, Elsevier

    Professor Yasushi Hirota

  162. Interleukin (IL)-17A Stimulates IL-8 Secretion, Cyclooxygensase-2 Expression, and Cell Proliferation of Endometriotic Stromal Cells

    Article • Endocrinology, March 2008, Endocrine Society

    Professor Shigeru Taketani, Professor Yasushi Hirota

  163. Basic and Translational Research on Proteinase-Activated Receptors: Proteinase-Activated Receptors in Female Reproductive Tissues and Endometriosis

    Article • Journal of Pharmacological Sciences, January 2008, Japanese Pharmacological Society

    Professor Yasushi Hirota

  164. The Presence of Midkine and its Possible Implication in Human Ovarian Follicles

    Article • American Journal of Reproductive Immunology, October 2007, Wiley

    Professor Yasushi Hirota

  165. Metformin Suppresses Interleukin (IL)-1β-Induced IL-8 Production, Aromatase Activation, and Proliferation of Endometriotic Stromal Cells

    Article • The Journal of Clinical Endocrinology & Metabolism, August 2007, Endocrine Society

    Professor Yasushi Hirota

  166. Expression of toll-like receptors 2, 3, 4, and 9 genes in the human endometrium during the menstrual cycle

    Article • Journal of Reproductive Immunology, June 2007, Elsevier

    Professor Yasushi Hirota

  167. Selective increase in high molecular weight adiponectin concentration in serum of women with preeclampsia

    Article • Journal of Reproductive Immunology, February 2007, Elsevier

    Professor Yasushi Hirota

  168. FR 167653, a p38 mitogen-activated protein kinase inhibitor, suppresses the development of endometriosis in a murine model

    Article • Journal of Reproductive Immunology, December 2006, Elsevier

    Professor Yasushi Hirota

  169. The Expression and Possible Roles of Chemokine CXCL11 and Its Receptor CXCR3 in the Human Endometrium

    Article • The Journal of Immunology, December 2006, The American Association of Immunologists

    Professor Yasushi Hirota

  170. Expression of Adiponectin Receptors and Its Possible Implication in the Human Endometrium

    Article • Endocrinology, July 2006, Endocrine Society

    Professor Yasushi Hirota

  171. Recurrence of ovarian endometrioma after laparoscopic excision

    Article • Human Reproduction, April 2006, Oxford University Press (OUP)

    Professor Yasushi Hirota

  172. Mechanical stretch upregulates IGFBP-1 secretion from decidualized endometrial stromal cells

    Article • AJP Endocrinology and Metabolism, February 2006, American Physiological Society

    Professor Yasushi Hirota

  173. Sciatic endometriosis diagnosed by computerized tomography–guided biopsy and CD10 immunohistochemical staining

    Article • Fertility and Sterility, November 2005, Elsevier

    Professor Yasushi Hirota

  174. Concentration of Adiponectin in Peritoneal Fluid is Decreased in Women with Endometriosis

    Article • American Journal of Reproductive Immunology, October 2005, Wiley

    Professor Yasushi Hirota

  175. Activation of protease-activated receptor 2 stimulates proliferation and interleukin (IL)-6 and IL-8 secretion of endometriotic stromal cells

    Article • Human Reproduction, August 2005, Oxford University Press (OUP)

    Professor Yasushi Hirota

  176. Serum adiponectin concentrations are decreased in women with endometriosis

    Article • Human Reproduction, July 2005, Oxford University Press (OUP)

    Professor Yasushi Hirota

  177. GnRH II as a possible cytostatic regulator in the development of endometriosis

    Article • Human Reproduction, July 2005, Oxford University Press (OUP)

    Professor Yasushi Hirota

  178. Possible Involvement of Thrombin/Protease-Activated Receptor 1 System in the Pathogenesis of Endometriosis

    Article • The Journal of Clinical Endocrinology & Metabolism, June 2005, Endocrine Society

    Professor Yasushi Hirota

  179. Changes in Plasma Coagulation Markers with Prophylactic Treatment of Low Molecular Weight Heparin after Cesarean Section

    Article • Seminars in Thrombosis and Hemostasis, June 2005, Thieme Publishing Group

    Professor Yasushi Hirota

  180. Development of an experimental model of endometriosis using mice that ubiquitously express green fluorescent protein

    Article • Human Reproduction, April 2005, Oxford University Press (OUP)

    Professor Yasushi Hirota

  181. Elevated interleukin-16 levels in the peritoneal fluid of women with endometriosis may be a mechanism for inflammatory reactions associated with endometriosis

    Article • Fertility and Sterility, April 2005, Elsevier

    Professor Yasushi Hirota

  182. Possible implication of midkine in the development of endometriosis

    Article • Human Reproduction, April 2005, Oxford University Press (OUP)

    Professor Yasushi Hirota

  183. Evidence for the Presence of Protease-Activated Receptor 2 and Its Possible Implication in Remodeling of Human Endometrium

    Article • The Journal of Clinical Endocrinology & Metabolism, March 2005, Endocrine Society

    Professor Yasushi Hirota

  184. Mechanical Stretch Stimulates Interleukin-8 Production in Endometrial Stromal Cells: Possible Implications in Endometrium-Related Events

    Article • The Journal of Clinical Endocrinology & Metabolism, February 2005, Endocrine Society

    Professor Yasushi Hirota

  185. Evidence for the Presence of Toll-Like Receptor 4 System in the Human Endometrium

    Article • The Journal of Clinical Endocrinology & Metabolism, January 2005, Endocrine Society

    Professor Yasushi Hirota

  186. Concentration of osteoprotegerin (OPG) in peritoneal fluid is increased in women with endometriosis

    Article • Human Reproduction, October 2004, Oxford University Press (OUP)

    Professor Yasushi Hirota

  187. Protease-activated receptor 2 (PAR2) stimulates the proliferation of endometriotic stromal cells via mitogen-activated protein kinases (MAPKs)

    Article • Fertility and Sterility, September 2004, Elsevier

    Professor Yasushi Hirota

  188. Evidence for the Presence of Angiogenin in Human Testis

    Article • Journal of Andrology, May 2004, Wiley

    Professor Yasushi Hirota

  189. Upregulation of Interleukin-8 by Hypoxia in Human Ovaries

    Article • American Journal of Reproductive Immunology, October 2003, Wiley

    Professor Yasushi Hirota

  190. Possible Roles of Thrombin-Induced Activation of Protease-Activated Receptor 1 in Human Luteinized Granulosa Cells

    Article • The Journal of Clinical Endocrinology & Metabolism, August 2003, Endocrine Society

    Professor Yasushi Hirota

  191. Concentrations of Interferon-gamma-Induced Protein-10 (IP-10), an Antiangiogenic Substance, are Decreased in Peritoneal Fluid of Women with Advanced Endometriosis

    Article • American Journal of Reproductive Immunology, July 2003, Wiley

    Professor Yasushi Hirota

  192. Characteristic images of deeply infiltrating rectosigmoid endometriosis on transvaginal and transrectal ultrasonography

    Article • Human Reproduction, June 2003, Oxford University Press (OUP)

    Professor Yasushi Hirota

  193. Endometrial Stromal Cells Undergoing Decidualization Down-Regulate Their Properties to Produce Proinflammatory Cytokines in Response to Interleukin-1β via Reduced p38 Mitogen-Activated Protein Kinase Phosphorylation

    Article • The Journal of Clinical Endocrinology & Metabolism, May 2003, Endocrine Society

    Professor Yasushi Hirota

  194. Elevated Serum Soluble Vascular Endothelial Growth Factor Receptor 1 (sVEGFR-1) Levels in Women with Preeclampsia

    Article • The Journal of Clinical Endocrinology & Metabolism, May 2003, Endocrine Society

    Professor Yasushi Hirota

  195. Akt as a possible intracellular mediator for decidualization in human endometrial stromal cells

    Article • Molecular Human Reproduction, May 2003, Oxford University Press (OUP)

    Professor Yasushi Hirota

  196. The possible role of thrombin receptor on human granulosa cells

    Article • Fertility and Sterility, September 2002, Elsevier

    Professor Yasushi Hirota

  197. Concentrations of interferon-induced protein (IP-10), an antiangiogenic substance, are decreased in peritoneal fluid of women with advanced endometriosis

    Article • Fertility and Sterility, September 2002, Elsevier

    Professor Yasushi Hirota

  198. Recurrence of ovarian endometrioma after laparoscopic excision

    Article • Fertility and Sterility, February 2002, Elsevier

    Professor Yasushi Hirota

  199. Interleukin (IL)-16 in peritoneal fluid from women with endometriosis

    Article • Fertility and Sterility, February 2002, Elsevier

    Professor Yasushi Hirota