Correlating Clinical and Anatomic Pathology

What is it about?

Summarizes material presentation in a continuing education course on integrating clinical and anatomical pathology data. A weight of evidence approach is necessary to fully understand the relationship between study findings and the test article and to interpret safety findings in toxicology studies. Basic principles for correlating anatomic pathology and clinical pathology findings and for integrating these with other study endpoints are reviewed, with case examples to illustrate the collaborative effort required between clinical and anatomical pathologists. In addition, the diagnostic utility of traditional liver biomarkers is discussed using results from a meta-analysis of rat hepatobiliary marker and histopathology data. This discussion also includes examples of traditional and novel liver and renal biomarker data implementation in nonclinical toxicology studies, to illustrate the relationship between discrete changes in biochemistry and tissue morphology.

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