What is it about?
Crush injuries in peripheral nerves are frequent and induce long-term disability with motor and sensory deficits. Due to axonal and myelin sheath disruptions, strategies for optimized axonal regeneration are needed. Multipotent mesenchymal stromal cells (MSC) are promising because of their anti-inflammatory properties and secretion of neurotrophins. The present study investigated the effect of canine adipose tissue MSC (Ad-MSC) transplantation in an experimental sciatic nerve crush injury.
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Why is it important?
Traumatic peripheral nerve injury in dogs is frequent and cause long term disability, as well as negative psychological impact in the owners. The current therapeutic approachs are limited and usually cause disappointement in veterinarians and owners.
Perspectives
We hope that our results stimulate researchers to develop new protocols of cell-based therapy for peripheral nerve injury in dogs
Dr. Rogerio Amorim
School of Veterinary Medicine and Animal Science - Sao Paulo State University - Unesp
Read the Original
This page is a summary of: Canine Adipose-Derived Mesenchymal Stromal Cells Enhance Neuroregeneration in a Rat Model of Sciatic Nerve Crush Injury, Cell Transplantation, October 2018, SAGE Publications,
DOI: 10.1177/0963689718809045.
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