What is it about?
If cells from the cornea (front of the eye) are exposed to a hyperosmolar environment, the increase their expression of small proteins which are cross linked to form a cornified layer. This form of stress induced process is mediated by mitogen activated protein kinases.
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Why is it important?
This kind of stress is common in dry eye, a disease that is difficult to treat
Perspectives
Hyperosmolar stress regulates cornified envelope proteins.
Prof Louis Tong
National University of Singapore
Read the Original
This page is a summary of: Hyperosmolarity-Induced Cornification of Human Corneal Epithelial Cells Is Regulated by JNK MAPK, Investigative Ophthalmology & Visual Science, February 2008, Association for Research in Vision and Ophthalmology (ARVO),
DOI: 10.1167/iovs.07-0569.
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