What is it about?
The CD56(bright) cells are decreased in healthy elderly individuals, the CD56(dim) subset is expanded. The expression of CD57, a marker of highly differentiated NK cells, is increased in the elderly.
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Why is it important?
This supports the notion that a remodeling process of NK cell subsets occurs in aging with a gradual decrease in more immature CD56(bright) NK cells and an increase in highly differentiated CD56(dim) CD57+ NK cells. This NK cell redistribution can explain many of the phenotypic and functional changes in NK cells
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This page is a summary of: Immunosenescence of Human Natural Killer Cells, Journal of Innate Immunity, January 2011, Karger Publishers,
DOI: 10.1159/000328005.
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