What is it about?

It is well-established that obesity associates with a multitude of negative health outcomes however osteoporosis stands as an exception, a state in which overweight or mild obesity might be favorable. Our study is designed to address some of the important knowledge gaps regarding obesity and the impact on bone health in adulthood. Our long-term study of obesity in adult mice showed that despite increases in fat stores, including fat housed within bone, obesity failed to harm bone. Early aging, in contrast to obesity, turned out to be the main regulator of bone loss.

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Why is it important?

This is the first preclinical study- in males or females -to rigorously quantify bone marrow fat long-term in adults in response to diet- induced obesity, along with bone quantity and quality. This dietary bone and bone fat ‘dose response’ over time is vital to show obesity’s impact on bone health.


It is notable that despite obesity increasing fat stores including those housed within bone, it was aging that emerged as the main regulator of bone health.

Dr Maya Styner
University of North Carolina at Chapel Hill, Department of Medicine, Division of Endocrinology

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This page is a summary of: Diet Stimulated Marrow Adiposity Fails to Worsen Early, Age-Related Bone Loss, Obesity Facts, January 2024, Karger Publishers,
DOI: 10.1159/000536159.
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