What is it about?

Sestrins are proteins important in biological systems. In this review we summarize the recent advances on understanding of their role in autophagy and ROS regulation with broad reflex in health as well in aging and disease condition

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Why is it important?

The potent antioxidant and autophagic effects regulated by Sestrins confer neuronal stress tolerance to toxic injuries, and neuroprotection in neurodegenerative disorders that are closely linked to oxidative stress, such as Parkinson’s disease and Alzheimer’s disease.


Future studies are required to further validate such potential of Sestrins as biomarkers and therapeutic targets against these disorders, and to fully understand how their multiple functions are interrelated and coordinated at systems-level.

Marco Cordani

Read the Original

This page is a summary of: Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease, Oxidative Medicine and Cellular Longevity, May 2019, Hindawi Publishing Corporation, DOI: 10.1155/2019/1283075.
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