What is it about?
Intensive care unit patients with infective endocarditis had the highest heparin-binding protein (HBP) serum levels, whereas the patients with bacterial meningitis had the lowest serum levels of cortisol. In addition, elevated serum levels of cortisol and monocyte chemoattractant protein 1 correlated positively with the severe course of sepsis.
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Why is it important?
The results are supporting the notion that pathophysiology of sepsis is significantly influenced by the site of infection.
Perspectives
To sum up the data was not easy because of the complexity of sepsis induced inflammatory responses.
prof. dr.-med. Michal Holub
Charles University
Read the Original
This page is a summary of: Selected Biomarkers Correlate with the Origin and Severity of Sepsis, Mediators of Inflammation, January 2018, Hindawi Publishing Corporation,
DOI: 10.1155/2018/7028267.
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